Cetirizine dihydrochloride_83881-52-1_DataSheet_MedChemExpress

Product Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Cetirizine dihydrochloride83881-52-1HY-17042A461.81C21H27Cl3N2O3>98%Solubility:DMSO 92 mg/mL; Water 92 mg/mL ; Ethanol <1 mg/mL Mechanisms: Pathways:GPCR/G protein; Target:Histamine Receptor Biological Activity:Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and aCetirizine2Hclasecondgenerationantihistamineisamajormetaboliteofhydroxyzineandaracemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever,angioedema, and urticaria. IC50 value: Target: Histamine H1 receptor Cetirizine crosses the blood-brain barrier only slightly, reducing the sedative side-effect commonwith older antihistamines. It has also been shown to inhibit eosinophil chemotaxis and LTB4 release.At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients withatopic dermatitis. The levorotary enantiomer of cetirizine, known as levocetirizine, is the more activepyform. From Wikipedia....References:[1]. Naclerio RM. Additional properties of cetirizine, a new H1 antagonist. Allergy Proc. 1991 May-Jun;12(3):187-91. [2]. Meh A, et al. Effect of cetirizine, a histamine (H(1)) receptor antagonist, on bone modeling during[],,(())pg,ggorthodontic tooth movement in rats. Am J Orthod Dentofacial Orthop. 2011 Apr;139(4):e323-9. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com 18 Wilkinson Way, Princeton, NJ 08540,USAess.com Web: www.medchemexpress.comEmail: info@medchemexpr