Salidroside 目录号M39
化学数据
分子量分子式CAS号储存条件
300.3C14H20O710338-51-93年 -20°C 粉末状
溶解性（25°C）
DMSO 10 mMWater <1 mMEthanol <1 mM
生物活性
Salidroside suppressed OGD/re-oxygenation-induced reactive oxygen species (ROS) production, p53 mitochondrial translocation and cyclophilin D (Cyp-D)association as well as mitochondrial membrane potential (MMP) decrease in H9c2 cells. Salidroside activated Akt and promoted transcription of NF-E2-relatedfactor 2 (Nrf2)-regulated genes (heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO-1)). Salidroside alleviated the pulmonary symptoms of PQ-induced ALI, at least partially, by repressing inflammatory cell infiltration and the expression of TGF-β1 resulting in delayed lung fibrosis. Salidroside exerts aprotective effect in CLP-induced sepsis by attenuating the proinflammatory responses, enhancing bacterial clearance, and preserving adaptive immunity.Salidroside may be a promising therapeutic strategy for the treatment of sepsis. Salidroside decreased the ST elevation induced by ISO, decreased serum levelsof CK-MB, LDH, TNF-α, IL-6, SOD, and MDA. In addition, Salidroside increased SOD activity and decreased MDA content in myocardial tissue.Salidroside alsodecreased Nox2 and 4, NF-κBP65, P-NF-κBP65, and AP1 protein levels in the heart.
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
小鼠
重量 (kg)体表面积 (m2)Km 系数
0.020.0073
动物 B的Km系数动物 A的Km系数
大鼠0.150.0256
兔1.80.1512
豚鼠0.40.058
仓鼠0.080.025
狗100.520
动物 A (mg/kg) = 动物 B (mg/kg) ×
例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。
参考文献
Effects of Salidroside on Myocardial Injury In Vivo In Vitro via Regulation of Nox/NF-κB/AP1 Pathway. Zhu L, et al. Inflammation. 2015 Feb 15. PMID: 25682470.
Salidroside rescued mice from experimental sepsis through anti-inflammatory and anti-apoptosis effects. Liu S, et al. J Surg Res. 2015 Jan 14. PMID: 256765.
Salidroside alleviates paraquat-induced rat acute lung injury by repressing TGF-β1 expression. Zhang Z, et al. Int J Clin Exp Pathol. 2014 Dec 1;7(12):8841-7. PMID: 25674253.
Salidroside protects against premature senescence induced by ultraviolet B irradiation in human dermal fibroblasts. Mao GX, et al. Int J Cosmet Sci. 2015 Jan 30. PMID: 25639473.
Salidroside inhibits oxygen glucose deprivation (OGD)/re-oxygenation-induced H9c2 cell necrosis through activating of Akt-Nrf2 signaling. Zheng K, et al. Biochem Biophys Res Commun. 2014 Aug 15;451(1):79-85. PMID: 25063033.